Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F24%3A00602502" target="_blank" >RIV/61389013:_____/24:00602502 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10488855
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/sm/d4sm00851k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D4SM00851K" target="_blank" >10.1039/D4SM00851K</a>

Result language
angličtina
Original language name
Interpolyelectrolyte complexes of a biguanide cationic polyelectrolyte: formation of core/corona nanoparticles with double-hydrophilic diblock polyanion
Original language description
Biguanide-based cationic polyelectrolytes are used as key components of interpolyelectrolyte complexes bolstering alginate hydrogel microcapsules employed in cell therapies. Nevertheless, electrostatic complexation of these unique polycations has not been studied before. In this study, the interaction between biguanide condensates and anionic polyelectrolytes with carboxylate groups was studied on a model system of a metformin condensate (MFC) and an anionic diblock polyelectrolyte poly(methacrylic acid)-block-poly(ethylene oxide) (PMAA–PEO). The formation of MFC/PMAA–PEO core–corona nanoparticles was followed by static, dynamic and electrophoretic light scattering and by isothermal titration calorimetry and their internal structure was investigated by small angle neutron scattering and cryogenic transmission electron microscopy. It was found that the aggregation of PMAA–PEO chains induced by MFC occurred at much lower MFC/PMAA–PEO ratios that would correspond to the isoelectric point, thus yielding strongly negatively charged nanoparticles, suggesting the role of specific (non-electrostatic) interactions in the stabilization of the complex between PMAA and MFC.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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