Precise control of molecular weight characteristics of charge-shifting poly(2-(N,N-dimethylamino)ethylacrylate) synthesized by reversible addition-fragmentation chain transfer polymerization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00605410" target="_blank" >RIV/61389013:_____/25:00605410 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/marc.202400640" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/marc.202400640</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/marc.202400640" target="_blank" >10.1002/marc.202400640</a>
Alternative languages
Result language
angličtina
Original language name
Precise control of molecular weight characteristics of charge-shifting poly(2-(N,N-dimethylamino)ethylacrylate) synthesized by reversible addition-fragmentation chain transfer polymerization
Original language description
Poly(2-(N,N-dimethylamino)ethyl acrylate) (PDMAEA) is a promising charge-shifting polycation with the capacity to form a range of morphologically distinct polyelectrolyte assemblies. Nevertheless, the basic character of the monomer and its hydrolytic instability impedes its controlled synthesis to higher molecular weight (MW). Herein, the reversible addition-fragmentation chain transfer polymerization of DMAEA is reported using a tert-butanol/V70 initiator/trithiocarbonate-based chain transfer agent (CTA) polymerization setup. The CTA instability is demonstrated in the presence of the unprotonated tertiary amino group of the DMAEA monomer, which limits the control over the conversion and MW of the polymer. In contrast, the shielding of the amino groups by their protonation leads to polymerization with high conversions and excellent control over MWs of polymer up to 100 000 g mol−1. Hydrolytic degradation study at pH values ranging from 5 to 9 reveals that both basic and protonated PDMAEA undergo a pH-dependent hydrolysis. The proposed polymerization conditions provide a means of synthesizing PDMAEA with well-controlled characteristics, which are beneficial for controlling the complexation processes during the formation of various polyelectrolyte assemblies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA24-10980S" target="_blank" >GA24-10980S: Bio-responsive polycationic vectors for genetic vaccine delivery</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Rapid Communications
ISSN
1022-1336
e-ISSN
1521-3927
Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2400640
UT code for WoS article
001357331000001
EID of the result in the Scopus database
2-s2.0-85207932091