Liraglutide-conjugated poly(methyl vinyl ether-alt-maleic acid)-coated core-shell upconversion nanoparticles for theranostics of diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637800" target="_blank" >RIV/61389013:_____/25:00637800 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00637800 RIV/00023001:_____/25:00085775 RIV/46747885:24530/25:00014635 RIV/00216208:11110/25:10500135
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.5c11275" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.5c11275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.5c11275" target="_blank" >10.1021/acsami.5c11275</a>
Alternative languages
Result language
angličtina
Original language name
Liraglutide-conjugated poly(methyl vinyl ether-alt-maleic acid)-coated core-shell upconversion nanoparticles for theranostics of diabetes
Original language description
In the diagnostics of diabetes, specific targeting of drugs (e.g., liraglutide) to insulin-deficient β-cells with their simultaneous noninvasive imaging is currently needed. In this report, liraglutide (LGL)-conjugated poly(methyl vinyl ether-alt-maleic acid) (PMVEMA)-coated core–shell NaYF4:Yb,Er,Fe@NaYF4:Nd upconversion nanoparticles (CS-UCNPs) have been developed, thoroughly physicochemically characterized, and evaluated in vivo. Novel codoping of Fe2+, Yb3+, and Er3+ ions in the host NaYF4 induced upconversion emission in the red region at both 980 and 808 nm excitation, making the particles suitable for deep-tissue imaging. Surface functionalization with PMVEMA provided colloidal stability and facilitated covalent conjugation with LGL, enabling targeted binding to GLP-1 receptors on pancreatic β-cells, increasing glucose-stimulated insulin secretion from isolated Langerhans islets. Biocompatibility of CS-UCNP@PMVEMA-LGL nanoparticles was confirmed by the trypan blue dye exclusion assay. When the fluorescent dye Flamma was conjugated to the nanoparticles, in vivo fluorescence imaging revealed significantly enhanced accumulation of CS-UCNP@PMVEMA-LGL-Flamma nanoparticles in the pancreas 24 h after intramuscular injection compared with intravenous administration, with luminescence intensity approximately doubled. The improved pancreatic targeting efficiency was attributed to enhanced binding to GLP-1 receptors. Confocal microscopy and elemental analysis confirmed receptor-mediated uptake of the nanoparticles by internalization and their localization within pancreatic β-cells. These findings highlight the potential of CS-UCNP@PMVEMA-LGL nanoparticles as biocompatible targetable imaging agents with future applications in pancreatic diagnostics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Materials and Interfaces
ISSN
1944-8244
e-ISSN
1944-8252
Volume of the periodical
17
Issue of the periodical within the volume
30
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
42863-42876
UT code for WoS article
001530081300001
EID of the result in the Scopus database
2-s2.0-105012784149