Tannic and boric acid crosslinked glycerol-citrate polyesters: structural, mechanical and biological performance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641110" target="_blank" >RIV/61389013:_____/25:00641110 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S001430572500655X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001430572500655X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2025.114367" target="_blank" >10.1016/j.eurpolymj.2025.114367</a>
Alternative languages
Result language
angličtina
Original language name
Tannic and boric acid crosslinked glycerol-citrate polyesters: structural, mechanical and biological performance
Original language description
Functionalization of biodegradable polymers with naturally derived bioactive compounds is highly attractive in biomedical science and engineering to enhance the chemical, mechanical, and biological properties of existing polyesters. Here, we report a simple synthesis of glycerol–citrate (GCA) polyesters dual-crosslinked with tannic (TA) and boric acids (B), with GCA/TB1 and GCA/TB2 containing 1 and 2 wt% of each crosslinker, respectively. A detailed investigation was conducted to examine their structural features, underlying reaction mechanisms, and thermal, mechanical, and biological properties, as well as biodegradation. Structural (ssNMR, FTIR, XRD), thermal (DSC/TG), and microscopic (SEM) analyses revealed that the crosslinked systems form an amorphous, more densely connected polymer network, providing evidence of borate–ester bonds and tannic acid incorporation. Mechanical properties were assessed using three complementary methods—macromechanical tensile testing, nanoindentation, and ultrasound—and showed that GCA/TB1 exhibited the highest Young’s modulus, yield stress, hardness, and tensile strength, associated with a more uniform surface, smoother fracture morphology, and effective crosslinking. The modified polyesters also displayed enhanced hydrophilicity and slower, more controlled hydrolytic degradation, accompanied by milder pH changes, beneficial for improved tissue response and biocompatibility. In vitro tests demonstrated that 50 % extracts of GCA/TB1 and GCA/TB2 supported osteoblast viability above 75 %, compared to ∼ 10 % for pure GCA, while retaining measurable antibacterial activity, particularly against Staphylococcus aureus. This work highlights how molecular-level modifications can effectively tune the performance of simple, bio-based citrate polyesters, providing a versatile platform for sustainable and adaptable scaffold materials with potential biomedical applications, including drug delivery.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Polymer Journal
ISSN
0014-3057
e-ISSN
1873-1945
Volume of the periodical
241
Issue of the periodical within the volume
15 December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
114367
UT code for WoS article
001611099300002
EID of the result in the Scopus database
2-s2.0-105020373430