Polymeric micelles in advanced photodynamic therapy: design, delivery and translational prospects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00642280" target="_blank" >RIV/61389013:_____/25:00642280 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2590156725001240?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2590156725001240?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpx.2025.100439" target="_blank" >10.1016/j.ijpx.2025.100439</a>
Alternative languages
Result language
angličtina
Original language name
Polymeric micelles in advanced photodynamic therapy: design, delivery and translational prospects
Original language description
Photodynamic therapy (PDT) is widely studied and complex method useful as a minimally invasive cancer treatment strategy, relying on photosensitizers (PSs), light, and oxygen to induce cytotoxicity. Indeed, the controlled delivery of conventional PSs is the key factor in achieving effective treatment outcome. Among many drug delivery systems, the polymeric micelles represent a promising platform to address the solubility, stability, and delivery challenges associated with PSs. The design of micelles, constructed from hydrophilic and hydrophobic polymeric blocks in diverse structures, enables precise tailoring of carrier properties to optimize PS delivery. This paper focuses on the potential applications and limitations of polymer micelles for the controlled delivery of PSs in the field anticancer therapy. Various methods of synthesis, incorporation of PSs as well as their release and activation are described in detail. The effect of micellar system employment on circulation time, off-target effects, and both passive and active targeting are thoroughly depicted. Despite the clinical promise, the limitations of PDT including shallow tissue penetration and restricted applicability to superficial or endoscope-accessible tumors are discussed, as well as the future prospects consisting in red-shifted or two-photon absorption systems.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Pharmaceutics-X
ISSN
2590-1567
e-ISSN
2590-1567
Volume of the periodical
10
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
26
Pages from-to
100439
UT code for WoS article
001618435000001
EID of the result in the Scopus database
2-s2.0-105022645922