In vivo effects of focused shock waves on tumor tissue visualized by fluorescence staining techniques
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389021%3A_____%2F15%3A00441045" target="_blank" >RIV/61389021:_____/15:00441045 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/15:00441045 RIV/00216208:11110/15:10286360
Result on the web
<a href="http://dx.doi.org/10.1016/j.bioelechem.2014.08.019" target="_blank" >http://dx.doi.org/10.1016/j.bioelechem.2014.08.019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioelechem.2014.08.019" target="_blank" >10.1016/j.bioelechem.2014.08.019</a>
Alternative languages
Result language
angličtina
Original language name
In vivo effects of focused shock waves on tumor tissue visualized by fluorescence staining techniques
Original language description
Shock waves can cause significant cytotoxic effects in tumor cells and tissues both in vitro and in vivo.However,understanding the mechanisms of shock wave interaction with tissues is limited.We have studied in vivo effects of focused shock waves induced in the syngeneic sarcoma tumor model using the TUNEL assay,immunohistochemical detection of caspase-3 and hematoxylin-eosin staining.Shock waves were produced by a multichannel pulsed-electrohydraulic discharge generator with a cylindrical ceramic-coated electrode.In tumors treated with shock waves,a large area of damaged tissue was detected which was clearly differentiated from intact tissue. Localization and a cone-shaped region of tissue damage visualized by TUNEL reaction apparently correlated with the conical shape and direction of shock wave propagation determined by high-speed shadowgraphy.A strong TUNEL reaction of nuclei and nucleus fragments in tissue exposed to shock waves suggested apoptosis in this destroyed tumor area.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioelectrochemistry
ISSN
1567-5394
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
June
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
103-110
UT code for WoS article
000351977000017
EID of the result in the Scopus database
2-s2.0-84923383214