Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F16%3A00462586" target="_blank" >RIV/61389030:_____/16:00462586 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/16:10326405
Result on the web
<a href="http://dx.doi.org/10.1007/s11356-016-6472-0" target="_blank" >http://dx.doi.org/10.1007/s11356-016-6472-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-016-6472-0" target="_blank" >10.1007/s11356-016-6472-0</a>
Alternative languages
Result language
angličtina
Original language name
Albendazole in environment: faecal concentrations in lambs and impact on lower development stages of helminths and seed germination
Original language description
Albendazole (ABZ), widely used benzimidazole anthelmintic, administered to animals enters via excrements into environment and may impact non-target organisms. Moreover, exposure of lower development stages of helminths to anthelmintics may also encourage the development of drug-resistant strains of helminths. In present project, the kinetics of ABZ (10 mg kg(-1) p.o.) and its metabolite (ABZ.SO, ABZSO(2)) elimination in faeces from treated Texel lambs were studied using UHPLC/MS/MS with the aim to find out their concentrations achievable in the environment. Consequently, the effect of these compounds on lower development stages of Barber's pole worm (Haemonchus contortus) and on germination of white mustard (Sinapis alba) seeds was evaluated. The results showed that ABZ concentrations in faeces excreted in 4-60 h after treatment were above the concentrations lethal for H. contortus eggs. Moreover, pre-incubation with sub-lethal doses of ABZ and ABZ.SO did not increase the resistance of H. contortus eggs and larvae to anthelmintics. On the other hand, concentrations of ABZ and ABZ.SO in faeces are so high that might have negative influence on non-target soil invertebrates. As neither ABZ nor its metabolites affect the germination of mustard seeds, phytoremediation could be considered as potential tool for detoxification of ABZ in the environment.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-05325S" target="_blank" >GA15-05325S: Anthelmintics in plants – uptake, biotransformation and transcriptional response</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
13
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
13015-13022
UT code for WoS article
000378817300040
EID of the result in the Scopus database
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