Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00481221" target="_blank" >RIV/61389030:_____/17:00481221 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73584363
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.010" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2017.08.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.010" target="_blank" >10.1016/j.steroids.2017.08.010</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study
Original language description
A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
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Volume of the periodical
127
Issue of the periodical within the volume
NOV
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
46-55
UT code for WoS article
000413607900007
EID of the result in the Scopus database
2-s2.0-85028510908