Metabolism of ibuprofen in higher plants: A model Arabidopsis thaliana cell suspension culture system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00481319" target="_blank" >RIV/61389030:_____/17:00481319 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.envpol.2016.09.074" target="_blank" >http://dx.doi.org/10.1016/j.envpol.2016.09.074</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.envpol.2016.09.074" target="_blank" >10.1016/j.envpol.2016.09.074</a>
Alternative languages
Result language
angličtina
Original language name
Metabolism of ibuprofen in higher plants: A model Arabidopsis thaliana cell suspension culture system
Original language description
The uptake and metabolism of ibuprofen (IBU) by plants at the cellular level was investigated using a suspension culture of A. thaliana. Almost all IBU added to the medium (200 μM) was metabolized or bound to insoluble structures in 5 days. More than 300 metabolites were determined by liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis, and most of these are first reported for plants here. Although hydroxylated derivatives formed by oxidation on the isobutyl side chain were the main first-step products of IBU degradation, conjugates of these products with sugar, methyl and amino acid groups were the dominant metabolites in the culture. The main portion of total added IBU (81%) was accumulated in the extractable intracellular pool, whereas the cultivation medium fraction contained only 19%. The amount of the insoluble cell-wall-bound IBU was negligible (0.005% of total IBU).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA14-22593S" target="_blank" >GA14-22593S: Metabolism of selected non-steroidal anti-inflammatory drugs in plants and its environmental consequences</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Pollution
ISSN
0269-7491
e-ISSN
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Volume of the periodical
220
Issue of the periodical within the volume
JAN
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
383-392
UT code for WoS article
000390736700041
EID of the result in the Scopus database
2-s2.0-84992163553