Synthesis and in vitro anticancer activity of 23(23′)E-benzylidenespirostanols derived from steroid sapogenins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00485770" target="_blank" >RIV/61389030:_____/17:00485770 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/17:73585171
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.017" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2017.08.017</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.017" target="_blank" >10.1016/j.steroids.2017.08.017</a>

Result language
angličtina
Original language name
Synthesis and in vitro anticancer activity of 23(23′)E-benzylidenespirostanols derived from steroid sapogenins
Original language description
Benzylidenespirostanols were prepared by two-step synthesis including BF 3 ·Et 2 O-catalyzed aldol condensation of several acetylated steroid sapogenins with benzaldehyde followed by saponification. The obtained compounds showed moderate cytotoxicity against three cancer cell lines (T-lymphoblastic leukemia cell line CEM, breast carcinoma cell line MCF7 and cervical carcinoma cell line HeLa) and normal human fibroblasts (BJ). The most active of the five tested substances was 3c (lowest IC 50 for MCF7 cells 19.9 ± 0.1 µM) without any selectivity towards human cancer and normal cells, respectively.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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