A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F18%3A00492203" target="_blank" >RIV/61389030:_____/18:00492203 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.devcel.2018.04.011" target="_blank" >http://dx.doi.org/10.1016/j.devcel.2018.04.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.devcel.2018.04.011" target="_blank" >10.1016/j.devcel.2018.04.011</a>
Alternative languages
Result language
angličtina
Original language name
A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes
Original language description
Membrane surface charge is critical for the transient, yet specific recruitment of proteins with polybasic regions to certain organelles. In eukaryotes, the plasma membrane (PM) is the most electronegative compartment of the cell, which specifies its identity. As such, membrane electrostatics is a central parameter in signaling, intracellular trafficking, and polarity. Here, we explore which are the lipids that control membrane electrostatics using plants as a model. We show that phosphatidylinositol-4-phosphate (PI4P), phosphatidic acidic (PA), and phosphatidylserine (PS) are separately required to generate the electrostatic signature of the plant PM. In addition, we reveal the existence of an electrostatic territory that is organized as a gradient along the endocytic pathway and is controlled by PS/PI4P combination. Altogether, we propose that combinatorial lipid composition of the cytosolic leaflet of organelles not only defines the electrostatic territory but also distinguishes different functional compartments within this territory by specifying their varying surface charges.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA17-27477S" target="_blank" >GA17-27477S: Multifaceted analysis of diacylglycerol kinase family in plants</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental Cell
ISSN
1534-5807
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
465-480
UT code for WoS article
000435091700009
EID of the result in the Scopus database
2-s2.0-85046659170