Discovery of multi-megabase polymorphic inversions by chromosome conformation capture sequencing in large-genome plant species

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F18%3A00498272" target="_blank" >RIV/61389030:_____/18:00498272 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/tpj.14109" target="_blank" >http://dx.doi.org/10.1111/tpj.14109</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tpj.14109" target="_blank" >10.1111/tpj.14109</a>

Result language
angličtina
Original language name
Discovery of multi-megabase polymorphic inversions by chromosome conformation capture sequencing in large-genome plant species
Original language description
Chromosomal inversions occur in natural populations of many species, and may underlie reproductive isolation and local adaptation. Traditional methods of inversion discovery are labor-intensive and lack sensitivity. Here, we report the use of three-dimensional contact probabilities between genomic loci as assayed by chromosome-conformation capture sequencing (Hi-C) to detect multi-megabase polymorphic inversions in four barley genotypes. Inversions are validated by fluorescence in situ hybridization and Bionano optical mapping. We propose Hi-C as a generally applicable method for inversion discovery in natural populations.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/LO1204" target="_blank" >LO1204: Sustainable development of research in the Centre of the Region Haná</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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