Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00502554" target="_blank" >RIV/61389030:_____/19:00502554 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/19:80837 RIV/62157124:16370/19:43878252
Result on the web
<a href="http://dx.doi.org/10.1016/j.foodchem.2019.01.128" target="_blank" >http://dx.doi.org/10.1016/j.foodchem.2019.01.128</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.foodchem.2019.01.128" target="_blank" >10.1016/j.foodchem.2019.01.128</a>

Result language
angličtina
Original language name
Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
Original language description
Stilbenoids represent a large group of bioactive compounds, which occur in food and medicinal plants. Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX-1, COX-2 and 5-LOX. Piceatannol and pinostilbene showed activity comparable to the zileuton and ibuprofen, respectively. The anti-inflammatory potential of stilbenoids was further evaluated using THP-1 human monocytic leukemia cell line. Tests of the cytotoxicity on the THP-1 and HCT116 cell lines showed very low toxic effects. The tested stilbenoids were evaluated for their ability to attenuate the LPS-stimulated activation of NF-κB/AP-1. Most of the tested substances reduced the activity of NF-κB/AP-1 and later attenuated the expression of TNF-α. The effects of selected stilbenoids were further investigated on inflammatory signaling pathways. Non-prenylated stilbenoids regulated attenuation of NF-ĸB/AP-1 activity upstream by inhibiting the phosphorylation of MAPKs. A docking study used to in silico analyze the tested compounds confirmed their interaction with NF-ĸB, COX-2 and 5-LOX.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10609 - Biochemical research methods

Project
<a href="/en/project/GA16-07193S" target="_blank" >GA16-07193S: Anti-inflammatory activity of selected stilbenoids, 2-arylbenzofuranes and their metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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