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Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5 alpha-oleandrigenin derivatives

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00509603" target="_blank" >RIV/61389030:_____/19:00509603 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/19:73598536

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.ejmech.2019.07.028" target="_blank" >http://dx.doi.org/10.1016/j.ejmech.2019.07.028</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ejmech.2019.07.028" target="_blank" >10.1016/j.ejmech.2019.07.028</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5 alpha-oleandrigenin derivatives

  • Original language description

    Oleandrin, the major biologically active constituent of shrub Nerium oleander preparations of which have been used in traditional Mediterranean and Asian medicine, attracts a great deal of attention due to its pronounced anticancer activity. The synthesis of oleandrigenin model, 16β-hydroxy-3β-methoxy-5α-card-20(22)-enolide 16-acetate, from androstenolone acetate through 17β-(3-furyl)-intermediates has been developed. Several related 17β-(butenolidyl)- and 17β-(furyl)-androstane derivatives were synthesized and tested for in vitro cytotoxic and Na+/K+-ATP-ase inhibitory activities. Comparison of Na+/K+-ATP-ase inhibitory and cytotoxic activity underlines complex nature of the relationship.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Medicinal Chemistry

  • ISSN

    0223-5234

  • e-ISSN

  • Volume of the periodical

    180

  • Issue of the periodical within the volume

    OCT 15

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    13

  • Pages from-to

    417-429

  • UT code for WoS article

    000488307100032

  • EID of the result in the Scopus database

    2-s2.0-85068979371