Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5 alpha-oleandrigenin derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00509603" target="_blank" >RIV/61389030:_____/19:00509603 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/19:73598536
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejmech.2019.07.028" target="_blank" >http://dx.doi.org/10.1016/j.ejmech.2019.07.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2019.07.028" target="_blank" >10.1016/j.ejmech.2019.07.028</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5 alpha-oleandrigenin derivatives
Original language description
Oleandrin, the major biologically active constituent of shrub Nerium oleander preparations of which have been used in traditional Mediterranean and Asian medicine, attracts a great deal of attention due to its pronounced anticancer activity. The synthesis of oleandrigenin model, 16β-hydroxy-3β-methoxy-5α-card-20(22)-enolide 16-acetate, from androstenolone acetate through 17β-(3-furyl)-intermediates has been developed. Several related 17β-(butenolidyl)- and 17β-(furyl)-androstane derivatives were synthesized and tested for in vitro cytotoxic and Na+/K+-ATP-ase inhibitory activities. Comparison of Na+/K+-ATP-ase inhibitory and cytotoxic activity underlines complex nature of the relationship.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
—
Volume of the periodical
180
Issue of the periodical within the volume
OCT 15
Country of publishing house
FR - FRANCE
Number of pages
13
Pages from-to
417-429
UT code for WoS article
000488307100032
EID of the result in the Scopus database
2-s2.0-85068979371