Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00521469" target="_blank" >RIV/61389030:_____/20:00521469 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fphar.2019.01559/abstract" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphar.2019.01559/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphar.2019.01559" target="_blank" >10.3389/fphar.2019.01559</a>
Alternative languages
Result language
angličtina
Original language name
Exploring the anti-acne potential of Impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence.
Original language description
The Gram-positive bacterium Cutibacterium acnes (previously Propionibacterium acnes), plays an important role in the pathogenesis and progression of the dermatological skin disorder acne vulgaris. The methanolic extract of Helichrysum odoratissimum (HO-MeOH) was investigated for its ability to target bacterial growth and pathogenic virulence factors associated with acne progression. The GC-MS analysis of HO-MeOH identified α-humulene, α-curcumene and carophyllene as major constituents, which correlated with previous reports. The HO-MeOH extract exhibited potent antimicrobial activity against C. acnes (ATCC 6919) with an MIC of 7.81 µg/ml. It enhanced the antimicrobial activity of benzoyl peroxide (BPO). The extract showed high specificity against C. acnes cell aggregation at sub-inhibitory concentrations, preventing biofilm formation. Mature C. acnes biofilms were disrupted at a sub-inhibitory concentration of 3.91 µg/ml.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30405 - Medical biotechnology related ethics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Pharmacology
ISSN
1663-9812
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
30 January
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
1559
UT code for WoS article
000515382900001
EID of the result in the Scopus database
2-s2.0-85079419784