Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00531937" target="_blank" >RIV/61389030:_____/20:00531937 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73604571
Result on the web
<a href="http://doi.org/10.1016/j.bioorg.2020.104013" target="_blank" >http://doi.org/10.1016/j.bioorg.2020.104013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2020.104013" target="_blank" >10.1016/j.bioorg.2020.104013</a>
Alternative languages
Result language
angličtina
Original language name
Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs
Original language description
Continuing our studies aimed at A-ring modified vitamin D compounds, we designed novel 19-norcalcitriol derivatives bearing at C-2 pegylated chains of different lengths. The terminal fragments of these substituents contain hydroxyls or moieties possessing nitrogen and/or sulfur atoms capable of transition metal ions complexation. Also, two conjugate–type platinum(II) complexes of 19-norcalcitriol were obtained in which L-methionine served as chelating moiety. The convergent synthesis of the target 19-norcalcitriol analogs involved several steps with the crucial one being condensation of A-ring phosphine oxide and the known Grundmann ketone by Wittig-Horner reaction. Further elaboration of the 2-alkylidene substituent provided all final compounds which were then tested to determine their affinity for the vitamin D receptor and cytotoxic activity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
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Volume of the periodical
101
Issue of the periodical within the volume
AUG
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
104013
UT code for WoS article
000552635800005
EID of the result in the Scopus database
2-s2.0-85087363683