A review on steroid dimers: 2011–2019

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F20%3A00539950" target="_blank" >RIV/61389030:_____/20:00539950 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/20:73604977
Result on the web
<a href="http://doi.org/10.1016/j.steroids.2020.108736" target="_blank" >http://doi.org/10.1016/j.steroids.2020.108736</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2020.108736" target="_blank" >10.1016/j.steroids.2020.108736</a>

Result language
angličtina
Original language name
A review on steroid dimers: 2011–2019
Original language description
The first review article on steroid dimers by Li and Dias in 1997, followed by the second review and a book on steroid dimers by Nahar and Sarker in 2007 and 2012, respectively, covered steroid dimers reported until the end of 2010. Since then, there have been considerable amounts of research carried out on steroid dimers, prompting the need for another comprehensive review on this topic. Therefore, this present review appraises the literature published during the period 2011–2019 on various aspects of steroid dimers, including isolation from natural sources, synthesis and applications. A structured and systematic literature search was performed, using the key words: steroid dimer, steroidal dimer, dimeric steroid, bis-steroid, bis-steroidal conjugates, molecular umbrella, cephalostatins, ritterazines and crellastatins. Several databases like Web of Knowledge, Science Direct, PubMed and Google Scholar were consulted. During the period covered in this review, well over 200 new synthetic steroidal dimers, ring A-ring A connection being the major group, have been reported, only one natural steroid dimer has been isolated, and potential applications of steroid dimers in the treatment of cancers and tumors, and microbial infections have been indicated.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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