Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F21%3A00545912" target="_blank" >RIV/61389030:_____/21:00545912 - isvavai.cz</a>

Result on the web

<a href="http://doi.org/10.1038/s41477-021-00869-2" target="_blank" >http://doi.org/10.1038/s41477-021-00869-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41477-021-00869-2" target="_blank" >10.1038/s41477-021-00869-2</a>

Result language

angličtina

Original language name

Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins

Original language description

Crop breeding for resistance to pathogens largely relies on genes encoding receptors that confer race-specific immunity. Here, we report the identification of the wheat Pm4 race-specific resistance gene to powdery mildew. Pm4 encodes a putative chimeric protein of a serine/threonine kinase and multiple C2 domains and transmembrane regions, a unique domain architecture among known resistance proteins. Pm4 undergoes constitutive alternative splicing, generating two isoforms with different protein domain topologies that are both essential for resistance function. Both isoforms interact and localize to the endoplasmatic reticulum when co-expressed. Pm4 reveals additional diversity of immune receptor architecture to be explored for breeding and suggests an endoplasmatic reticulum-based molecular mechanism of Pm4-mediated race-specific resistance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF16_019%2F0000827" target="_blank" >EF16_019/0000827: Plants as a tool for sustainable global development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Plants

ISSN

2055-026X

e-ISSN

2055-0278

Volume of the periodical

7

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

327-341

UT code for WoS article

000627722200003

EID of the result in the Scopus database

2-s2.0-85102528569