The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F22%3A00557539" target="_blank" >RIV/61389030:_____/22:00557539 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/22:73610739

Result on the web

<a href="http://doi.org/10.1016/j.molp.2021.10.007" target="_blank" >http://doi.org/10.1016/j.molp.2021.10.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molp.2021.10.007" target="_blank" >10.1016/j.molp.2021.10.007</a>

Result language

angličtina

Original language name

The HB40-JUB1 transcriptional regulatory network controls gibberellin homeostasis in Arabidopsis

Original language description

The gibberellins (GAs) are phytohormones that play fundamental roles in almost every aspect of plant growth and development. Although GA biosynthetic and signaling pathways are well understood, the mechanisms that control GA homeostasis remain largely unclear in plants. Here, we demonstrate that the homeobox transcription factor (TF) HB40 of the HD-Zip family regulates GA content at two additive control levels in Arabidopsis thaliana. We show that HB40 expression is induced by GA and in turn reduces the levels of endogenous bioactive GAs by simultaneously reducing GA biosynthesis and increasing GA deactivation. Consistently, HB40 overexpression leads to typical GA-deficiency traits, such as small rosettes, reduced plant height, delayed flowering, and male sterility. By contrast, a loss-of-function hb40 mutation enhances GA-controlled growth. Genome-wide RNA sequencing combined with molecular-genetic analyses revealed that HB40 directly activates the transcription of JUNGBRUNNEN1 (JUB1), a key TF that represses growth by suppressing GA biosynthesis and signaling. HB40 also activates genes encoding GA 2-oxidases (GA2oxs), which are major GA-catabolic enzymes. The effect of HB40 on plant growth is ultimately mediated through the induction of nuclear growth-repressing DELLA proteins. Collectively, our results reveal the important role of the HB40-JUB1 regulatory network in controlling GA homeostasis during plant growth.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10611 - Plant sciences, botany

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Plant

ISSN

1674-2052

e-ISSN

1752-9867

Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

322-339

UT code for WoS article

000770976200016

EID of the result in the Scopus database

2-s2.0-85120794220