Epigenetic targeting of transposon relics: beating the dead horses of the genome?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F22%3A00561925" target="_blank" >RIV/61389030:_____/22:00561925 - isvavai.cz</a>
Alternative codes found
RIV/67985939:_____/22:00561925 RIV/00216208:11310/22:10445403
Result on the web
<a href="https://doi.org/10.1080/15592294.2021.2022066" target="_blank" >https://doi.org/10.1080/15592294.2021.2022066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15592294.2021.2022066" target="_blank" >10.1080/15592294.2021.2022066</a>
Alternative languages
Result language
angličtina
Original language name
Epigenetic targeting of transposon relics: beating the dead horses of the genome?
Original language description
Transposable elements (TEs) have been seen as selfish genetic elements that can propagate in a host genome. Their propagation success is however hindered by a combination of mechanisms such as mutations, selection, and their epigenetic silencing by the host genome. As a result, most copies of TEs in a given genome are dead relics: their sequence is too degenerated to allow any transposition. Nevertheless, these TE relics often, but not always, remain epigenetically silenced, and if not to prevent transposition anymore, one can wonder the reason for this phenomenon. The mere self-perpetuating loop inherent to epigenetic silencing could alone explain that even when inactive, TE copies remain silenced. Beyond this process, nevertheless, antagonistic selective forces are likely to act on TE relic silencing. Especially, without the benefit of preventing transposition, TE relic silencing may prove deleterious to the host fitness, suggesting that the maintenance of TE relic silencing is the result of a fine, and perhaps case-by-case, evolutionary trade-off between beneficial and deleterious effects. Ultimately, the release of TE relics silencing may provide a ‘safe’ ground for adaptive epimutations to arise. In this review, we provide an overview of these questions in both plants and animals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/GA22-20240S" target="_blank" >GA22-20240S: Deciphering the biological significance of genomic imprinting</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epigenetics
ISSN
1559-2294
e-ISSN
1559-2308
Volume of the periodical
17
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1331-1344
UT code for WoS article
000738476000001
EID of the result in the Scopus database
2-s2.0-85122318163