Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F23%3A00575549" target="_blank" >RIV/61389030:_____/23:00575549 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/23:73619583
Result on the web
<a href="https://doi.org/10.3390/pr11061860" target="_blank" >https://doi.org/10.3390/pr11061860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pr11061860" target="_blank" >10.3390/pr11061860</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and Biological Evaluation of α-Tocopherol Derivatives as Potential Anticancer Agents
Original language description
α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells and efficient suppressors of tumors in experimental model cancer cell lines. They exhibit selective cytotoxicity against tumor cells and very limited or no toxicity toward nonmalignant cells. In the present work, a series of new α-tocopherol derivatives were synthesized as analogs of α-TS and α-TEA. The cytotoxic activity of obtained compounds was tested using three human cancer cell lines, including chronic lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7), cervical adenocarcinoma (HeLa), and normal human fibroblasts (BJ). The introduction of an alkyl substituent into the ether-linked acetic acid moiety in α-TEA increased anticancer activity. α-Tocopheryloxy-2-methylpropanoic acid with two additional geminal methyl groups was more active against CEM cells compared to α-TEA and non-toxic to normal cells. In order to acquire a deeper understanding of the biological activity of synthesized compounds, a molecular docking study was also conducted. Our research confirmed that vitamin E derivatives are interesting and valuable compounds in terms of their potential therapeutic use as anticancer agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Processes
ISSN
2227-9717
e-ISSN
2227-9717
Volume of the periodical
11
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1860
UT code for WoS article
001021158200001
EID of the result in the Scopus database
2-s2.0-85163884587