Photoprotective properties of new derivatives of kinetin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F23%3A00575733" target="_blank" >RIV/61389030:_____/23:00575733 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/23:73620981 RIV/61989592:15310/23:73620981 RIV/00098892:_____/23:10158518
Result on the web
<a href="https://doi.org/10.1007/s43630-023-00380-x" target="_blank" >https://doi.org/10.1007/s43630-023-00380-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s43630-023-00380-x" target="_blank" >10.1007/s43630-023-00380-x</a>
Alternative languages
Result language
angličtina
Original language name
Photoprotective properties of new derivatives of kinetin
Original language description
The chronic exposure of skin to ultraviolet (UV) radiation causes adverse dermal reactions, such as erythema, sunburn, photoaging, and cancer, by altering several signalling pathways associated with oxidative stress, inflammation, and DNA damage. One of the possible UV light protection strategies is the use of dermal photoprotective preparations. The plant hormone kinetin (N6-furfuryladenine, KIN) exhibits antioxidant and anti-senescent effects in human cells. Topically applied KIN also reduced some of the clinical signs of photodamaged skin. To improve the biological activities of KIN, several derivatives have been recently prepared and their beneficial effects on cell viability of skin cells exposed to UVA and UVB light were screened. Two potent candidates, 6-(tetrahydrofuran-2-yl)methylamino-9-(tetrahydrofuran-2-yl)purine (HEO) and 6-(thiophen-2-yl)methylamino-9-(tetrahydrofuran-2-yl)purine (HEO6), were identified. Here the effects of KIN, its N9-substituted derivatives the tetrahydropyran-2-yl derivative of KIN (THP), tetrahydrofuran-2-yl KIN (THF), HEO and HEO6 (both THF derivatives) on oxidative stress, apoptosis and inflammation in UVA- or UVB-exposed skin cell was investigated. Human primary dermal fibroblasts and human keratinocytes HaCaT pre-treated with the tested compounds were then exposed to UVA/UVB light using a solar simulator. All compounds effectively prevented UVA-induced ROS generation and glutathione depletion in both cells. HEO6 was found to be the most potent. All compounds also reduced UVB-induced caspase-3 activity and interleukin-6 release. THP and THF exhibited the best UVB protection. In conclusion, our results demonstrated the UVA- and UVB-photoprotective potential of KIN and its derivatives. From this point of view, they seem to be useful agents for full UV spectrum protective dermatological preparations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Photochemical & Photobiological Sciences
ISSN
1474-905X
e-ISSN
1474-9092
Volume of the periodical
22
Issue of the periodical within the volume
4
Country of publishing house
FR - FRANCE
Number of pages
13
Pages from-to
357-369
UT code for WoS article
000870608800001
EID of the result in the Scopus database
2-s2.0-85146697516