Cytotoxic Flavonoids from Lannea egregia Engl. & K. Krause

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F24%3A00600884" target="_blank" >RIV/61389030:_____/24:00600884 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/24:73627873

Result on the web

<a href="https://doi.org/10.34172/PS.2024.26" target="_blank" >https://doi.org/10.34172/PS.2024.26</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.34172/PS.2024.26" target="_blank" >10.34172/PS.2024.26</a>

Result language

angličtina

Original language name

Cytotoxic Flavonoids from Lannea egregia Engl. & K. Krause

Original language description

Lannea egregia Engl. & K. Krause (family: Anacardiaceae) is a well-known medicinal plant in Nigeria whose various parts have been shown to elicit several biological activities. This study specifically explored the leaf of L. egregia for potential cytotoxic compounds. Methods: n-Hexane, dichloromethane and methanolic extracts of the leaf were prepared using the Soxhlet apparatus and concentrated using the rotary evaporator. Compounds were isolated by reversed-phase preparative high-performance liquid chromatography, and the structures were determined by spectroscopic means. The methanolic extract and the isolated compounds were screened for cytotoxicity against HeLa and MCF-7 cancer cell lines, using the MTT assay. Results: Three flavonoids, myricetin (1), myricetin 3-O-α-L-rhamnoside (2) and quercetin 3-O-α-L-rhamnoside (3), were isolated from the methanolic extract of the leaf of L. egregia. The methanolic extract and compound 3 showed the most potent inhibition profiles against the cells, with IC50 values (Mean ± SEM) of 45.3 ± 1.5 µg/mL and 57.5 ± 0.4 µg/mL for the methanolic extract, and 36.5 ± 2.0 µM and 57.9 ± 10.1 µM for compound 3, against HeLa and MCF-7 cells, respectively. Conclusion: This work shows that L. egregia leaf is moderately cytotoxic, and rich in flavonoids, and the cytotoxicity of the extract is, at least partially, due to the presence of cytotoxic flavonoids. This is the first report on characterized isolated compounds from the leaf of L. egregia and the occurrence of flavonols in the leaf.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmaceutical Sciences

ISSN

1735-403X

e-ISSN

2383-2886

Volume of the periodical

30

Issue of the periodical within the volume

4

Country of publishing house

IR - IRAN, ISLAMIC REPUBLIC OF

Number of pages

6

Pages from-to

496-501

UT code for WoS article

001325506500009

EID of the result in the Scopus database

2-s2.0-85206467083