A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F24%3A00602612" target="_blank" >RIV/61389030:_____/24:00602612 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/24:73627898
Result on the web
<a href="https://doi.org/10.1016/j.molp.2024.11.001" target="_blank" >https://doi.org/10.1016/j.molp.2024.11.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molp.2024.11.001" target="_blank" >10.1016/j.molp.2024.11.001</a>
Alternative languages
Result language
angličtina
Original language name
A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis.
Original language description
Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of plants. Cytokinins, a class of plant hormones, regulate cell division and meristem maintenance. The cytokinin signaling pathway is well established in the model plant Arabidopsisthaliana. Several negative feedback mechanisms, tightly controlling cytokinin signaling output, have been described previously. In this study, we identified a new feedback mechanism executed through alternative splicing of the cytokinin receptor AHK4/CRE1. A novel splicing variant named CRE1int7 results from seventh intron retention, introducing a premature termination codon in the transcript. We showed that CRE1int7 is translated in planta into a truncated receptor lacking the C-terminal receiver domain essential for signal transduction. CRE1int7 can bind cytokinin but cannot activate the downstream cascade. We present a novel negative feedback mechanism of the cytokinin signaling pathway, facilitated by a decoy receptorthat can inactivate canonical cytokinin receptors via dimerization and compete with them for ligand binding. Ensuring proper plant growth and development requires precise control of the cytokinin signaling pathway at several levels. CRE1int7 represents a so-far unknown mechanism for fine-tuning the cytokinin signaling pathway in Arabidopsis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA23-07363S" target="_blank" >GA23-07363S: Alternative splicing fine-tunes cytokinin perception in planta</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Plant
ISSN
1674-2052
e-ISSN
1752-9867
Volume of the periodical
17
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
1850-1865
UT code for WoS article
001373778300001
EID of the result in the Scopus database
2-s2.0-85210061671