Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00638594" target="_blank" >RIV/61389030:_____/25:00638594 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41598-025-08450-z" target="_blank" >https://doi.org/10.1038/s41598-025-08450-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-08450-z" target="_blank" >10.1038/s41598-025-08450-z</a>
Alternative languages
Result language
angličtina
Original language name
Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways
Original language description
This study evaluated the protective effects of resveratrol against high-fat diet (HFD)-induced hepatic dysfunction and intestinal mucus layer depletion with a focus on antioxidant and anti-inflammatory mechanisms. HFD-fed rats were treated with resveratrol for 8 weeks, and various metabolic, molecular, and histological parameters were assessed. Resveratrol therapy significantly reduced body weight gain and adiposity, lowered plasma and hepatic oxidative stress markers, and restored endogenous antioxidant enzyme activity. Liver function markers including ALT, AST, and ALP were normalized in treated animals. RT-PCR analysis showed enhanced expression of lipid-metabolizing and antioxidant genes including PPAR alpha, CPT-1, Nrf2, and HO-1. Histological analysis revealed that resveratrol attenuated hepatic steatosis, collagen deposition, and fibrosis. Importantly, it preserved the goblet cell population within both intestinal crypts and villi, thereby maintaining the integrity of the gut-mucus barrier. These findings demonstrate that resveratrol exerts a multi-organ protective effect by simultaneously preserving intestinal mucus, improving hepatic antioxidant defenses, and reducing fibrosis. This study highlights a novel gut-liver axis mechanism for resveratrol action that extends beyond its well-known anti-obesity and mitochondrial benefits.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA23-05389S" target="_blank" >GA23-05389S: Novel CB2 and BChE modulators against Parkinson's disease and related pathologies</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
25162
UT code for WoS article
001527619700029
EID of the result in the Scopus database
2-s2.0-105010600694