Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1H-indoles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F25%3A00644040" target="_blank" >RIV/61389030:_____/25:00644040 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/25:73633178 RIV/61989592:15110/25:73633178
Result on the web
<a href="https://doi.org/10.1021/acs.jafc.5c14071" target="_blank" >https://doi.org/10.1021/acs.jafc.5c14071</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jafc.5c14071" target="_blank" >10.1021/acs.jafc.5c14071</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1H-indoles
Original language description
Parasitic nematodes are a significant concern in human and veterinary medicine as well as agriculture. In this study, we prepared twenty-seven 5-phenyl-1H-indole derivatives bearing various substituents on the phenyl ring and assessed their efficacy against nematodes. Using Caenorhabditis elegans, we selected the most potent compounds and evaluated their toxicity on selected animal and plant-parasitic nematode species. Compounds featuring 4-chloro, 4-fluoro, and 4-trifluoromethoxy groups on the phenyl ring inhibited the motility of exsheathed L3 larvae of Hemonchus contortus while exhibiting limited cytotoxicity in mammalian cell cultures. These compounds showed similar effects against the plant-parasitic nematodes Heterodera schachtii and Ditylenchus destructor, albeit with reduced potency. We propose that the compounds might act as inhibitors of mitochondrial complex II as inferred from molecular modeling, decreased mitochondrial membrane potential, and reduced activity in C. elegans complex II mutants.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40401 - Agricultural biotechnology and food biotechnology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Agricultural and Food Chemistry
ISSN
0021-8561
e-ISSN
1520-5118
Volume of the periodical
73
Issue of the periodical within the volume
52
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
33059-33069
UT code for WoS article
001640343100001
EID of the result in the Scopus database
2-s2.0-105026202968