Condensin II mediates resistance to genotoxic stress and prevents mitotic defects in Arabidopsis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F26%3A00648024" target="_blank" >RIV/61389030:_____/26:00648024 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1093/plphys/kiag022" target="_blank" >https://doi.org/10.1093/plphys/kiag022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/plphys/kiag022" target="_blank" >10.1093/plphys/kiag022</a>
Alternative languages
Result language
angličtina
Original language name
Condensin II mediates resistance to genotoxic stress and prevents mitotic defects in Arabidopsis
Original language description
Genome functions are regulated by chromatin and 3D chromosome organization. Dynamic condensation and relaxation of chromosomes during the cell cycle are largely controlled by the Condensin complexes. We mapped mutants in the Condensin II subunits SMC2A, CAP-D3 and CAP-H2 as hypersensitive to DNA-protein crosslink (DPC) inducers zebularine and ICRF-187. This suggested that Condensin II is required for resistance to genotoxic stress in Arabidopsis (Arabidopsis thaliana) and prompted us to explore the underlying phenotypes. We show that the role of Condensin II in resistance to zebularine is independent of DNA damage response signaling by SOG1 and homology-directed repair. Furthermore, we found that Arabidopsis Condensin II mutants have incompletely condensed mitotic chromosomes and show anaphase bridges. The anaphase bridges were more frequent upon treatment with zebularine or ICRF-187 and the duration of mitosis was prolonged. Altogether, we demonstrate that proper large-scale chromatin organization by Condensin II is important for resistance to DNA damage in Arabidopsis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Plant Physiology
ISSN
0032-0889
e-ISSN
1532-2548
Volume of the periodical
200
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
kiag022
UT code for WoS article
001686601900001
EID of the result in the Scopus database
2-s2.0-105029945409