Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F26%3A00648116" target="_blank" >RIV/61389030:_____/26:00648116 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1126/science.adx2867" target="_blank" >https://doi.org/10.1126/science.adx2867</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.adx2867" target="_blank" >10.1126/science.adx2867</a>
Alternative languages
Result language
angličtina
Original language name
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Original language description
Polyamines are often associated with ribosomes and are thought to stabilize their integrity. In Arabidopsis, the polyamine thermospermine (tSpm) affects xylem cell fate. tSpm induces translation of SUPPRESSOR-OF-ACAULIS51 (SAC51) and SAC51-LIKEs (SACLs), which inhibit heterodimerization of the xylem development proteins LONESOME-HIGHWAY (LHW) and TARGET-OF-MONOPTEROS5. Here, we report a methyltransferase, OVERACHIEVER, that methylates the peptidyl transferase center of the 25S ribosomal RNA (rRNA). Residue m3U2952 promotes functional tSpm binding to a specific site connecting the P-site transfer RNA (tRNA) with rRNA residues in the peptidyl transferase center. This interaction enhances the translation of SACLs but inhibits that of LHW. Our study uncovers the dependency between a conserved rRNA base methylation and a polyamine in orchestrating cell fate decisions, highlighting a role for the ribosome chemical landscape in translational regulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EH22_008%2F0004581" target="_blank" >EH22_008/0004581: TowArds Next GENeration Crops (TANGENC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2026
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
1095-9203
Volume of the periodical
391
Issue of the periodical within the volume
6786
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
694-699
UT code for WoS article
001692673100034
EID of the result in the Scopus database
2-s2.0-105030225040