Posttreatment plasma transforming growth factor beta 1 level predicts for late morbidity in parients with advanced head and neck cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F05%3AA0900HLJ" target="_blank" >RIV/61988987:17110/05:A0900HLJ - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Posttreatment plasma transforming growth factor beta 1 level predicts for late morbidity in parients with advanced head and neck cancer

Original language description

Methods and materials Between 2001-2002, 36 patients with advanced inoperable squamous head and neck cancer treated with radiotherapy with or without simultaneous chemotherapy were evaluated for their plasma TGF-b1 levels prior to the treatment, in the middle of the radiotherapy course and at the end of the treatment. The patients were assessed for treatment response and late morbidity. Results There were 29 eligible patients (pts), the rest being lost of follow-up. Of these 29 pts, 18 achieved completeresponse, 8 partial response and three pts progressed primarily. After a median follow-up of 16 months (range 3-28), we recorded 16 cases of grade > 1 late morbidity. We found that posttreatment elevated plasma TGF-b1 level predicts late morbidity grade>1 (p=0,05 see Graph 1) rather than pretreatment level (p=0,062). Conclusion Posttreatment plasma TGF-beta 1 level can predict late morbidity grade >1 in advanced head and neck cancer treated with radio(chemo)therapy.

Czech name

Poléčebná hodnota TGF-beta1 predikuje vyšší postradiační morbiditu u pacientů s pokročilými ORL malignitami

Czech description

Publikace hodnotí prediktivní význam TGF-beta1 u pacientů ozařovaných pro pokročilé nádory hlavy a krku. Výsledkem publikace je, že vysoká poléčebná hodnota TGF-beta1 predikuje vyšší pozdní postradiační morbiditu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NEOPLASMA

ISSN

0028-2685

e-ISSN

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Volume of the periodical

52

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

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UT code for WoS article

000232222100007

EID of the result in the Scopus database

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