Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F11%3AA12013XB" target="_blank" >RIV/61988987:17110/11:A12013XB - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Chronobiological aspects of reoxygenation impact on the heart rhythm disorders in Wistar rat model

Original language description

The clinical trials unanimously ascribe the increased risk of cardiac events to apneic episodes. The effect of reoxygenation after apneic episode on the development of ventricular arrhythmias have not been studied in detail as a function of the lightdarkcycle (LD cycle). We aimed to study the effect of reoxygenation on ventricular arrhythmia threshold (VAT) with respect to the LD cycle. Experiments were undertaken in female Wistar rats. The results clearly demonstrate the pro-arrhythmogenic effect of apneic episode regardless of the LD cycle. During reoxygenation, anti-arrhythmogenic effect (increase in VAT) was observed in the dark (active) part in contrast to pro-arrhythmogenic effect (decrease in VAT), which was demostrated during the light (nonactive) part of the day. These data suggest that heart rhythm disorders attributed to apneic episode can be attenuated or amplified by subsequent reoxygenation dependent on synchronization to the LD cycle.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Trendsin Comparative Biochem & Physiol

ISSN

0972-4540

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

15

Country of publishing house

IN - INDIA

Number of pages

7

Pages from-to

55-61

UT code for WoS article

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EID of the result in the Scopus database

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