A Review of the Total Synthesis of (+)-Lactacystin and its Analogs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F15%3AA1601FEH" target="_blank" >RIV/61988987:17110/15:A1601FEH - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A Review of the Total Synthesis of (+)-Lactacystin and its Analogs

Original language description

(+)-Lactacystin (1) is a natural substance that was firstly isolated in 1991 from bacteria of the genus Streptomyces, and it was studied for its ability to inhibit cell growth. Its mechanism of action is the inhibition of the 20S proteasome, which together with two 19S regulatory sub-units makes up the 26S proteasome complex; this is a part of the ubiquitin-proteasome pathway (UPP) in eukaryotic cells. 1 accumulates particularly in damaged cells, where the misfolded proteins occur, and subsequently it is able to arrest the cell cycle in the G1 phase by inhibition of the 20S proteasome, thus inducing apoptosis of the cell. 1 and its derivatives (e.g. omuralide (2), salinosporamide A (3), cinnabaramide A (4)) were tested as potential drug candidates forthe treatment of arthritis, asthma and cancer.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ARCH CARDIOVASC DIS

ISSN

1875-2136

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

20

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

20

Pages from-to

1980-2000

UT code for WoS article

000360489000002

EID of the result in the Scopus database

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