Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in maternal and umbilical cord blood at birth:Influence of co-administration of valproic or enzyme-unducing antiepileptic drugs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1701GTO" target="_blank" >RIV/61988987:17110/16:A1701GTO - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in maternal and umbilical cord blood at birth:Influence of co-administration of valproic or enzyme-unducing antiepileptic drugs

Original language description

Carmbamazepine is one of the three most frequently prescribed antiepileptic frugs in pregnancy. However, data relating to both carbamazepine and carbamazepine-10, 11-epoxide transplacental passage remain sparse. We have analysed in a cohort of 114 women carbamazepine and carbamazepine-10, 11-epoxide levels in maternal and umbilical cord serum at birth during 25 years retrospectively. The data showed the wide interindividual variability of the ratio of the umbilical cord/maternal level of both carbamaziepine and carbamazepine-10,11-epoxide. it is the first study show-ing the significant increase of the ratio of umbilical cord/maternal level of carbamazepine-10, 11-epoxide and carbamazepine-10,11-epoxide/carbamazepine ratio not only in maternal serum but also in umbilical cord in addition of valproic acid. The present study demonstates thal a concomitant administration of enzyme-inducing antiepileptics and valproic acid increases the maternal apparent oral clearance of carbamazepine significantly.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EPILEPSY RES

ISSN

0920-1211

e-ISSN

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Volume of the periodical

122

Issue of the periodical within the volume

May 01

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

84-90

UT code for WoS article

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EID of the result in the Scopus database

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