Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1701J66" target="_blank" >RIV/61988987:17110/16:A1701J66 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00089123 RIV/65269705:_____/16:00065515 RIV/00843989:_____/16:E0105516

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Original language description

Background: Extramedullary disease in multiple myeloma patients is an uncommon event occurring either at the time of diagnosis, or during disease progression/relapse. This manifestation is frequently associated with poor outcome and resistance to treatment. We evaluated chromosomal alterations of plasma cells of multiple myeloma patients with extramedullary relapse, either in the bone marrow (BM) or at extramedullary sites, and in previous BM collection by interphase fluorescence in situ hybridization. Material and methods: Thirty-one patients [25 BM plasma cells (BMPCs), 18 extramedullary tumor plasma cells], of which 12 had paired samples of BM and extramedullary plasma cells and 14 had previous collection of BM, were investigated for the presence of chromosomal aberrations (CHAs): del(17)(p13), del (13)(q14), 14q32 disruption, t(4; 14)(p16; q32), t(14; 16)(q32; q23), gain(1)(q21), and hyperdiploidy status. Results: Overall, in unrelated samples, t(4; 14) was more prevalent in extramedullary plasma cells, and hyperdiploidy was more frequent in BMPCs. In paired samples, there was a higher frequency of del(13) (q14) and 14q32 disruption in BMPCs. Frequency of all studied CHAs was higher in BMPCs of extramedullary patients than in their previous sample collection. Conclusion: These data show that plasma cells harbor more aberrations during their transformation into extramedullary form.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EUR J HAEMATOL

ISSN

0902-4441

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

93-100

UT code for WoS article

000378432900015

EID of the result in the Scopus database

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