Cognitive impairment and cortisol levels in first-episode schizophrenia patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1801N4Q" target="_blank" >RIV/61988987:17110/16:A1801N4Q - isvavai.cz</a>

Alternative codes found

RIV/00216224:14210/16:00090364 RIV/00843989:_____/16:E0105542 RIV/65269705:_____/16:00075964

Result on the web

<a href="http://dx.doi.org/10.1080/10253890.2016.1193146" target="_blank" >http://dx.doi.org/10.1080/10253890.2016.1193146</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10253890.2016.1193146" target="_blank" >10.1080/10253890.2016.1193146</a>

Result language

angličtina

Original language name

Cognitive impairment and cortisol levels in first-episode schizophrenia patients

Original language description

Many modalities of cognition are affected in schizophrenia. The most common findings include dysfunctions of episodic and working memory and of executive functions. Although an inverse correlation between cortisol level and memory function has been proven, few studies have focused on the relationship between cortisol level and cognitive impairment in patients with schizophrenia. In an open, naturalistic, prospective study, consecutively hospitalized males diagnosed with first-episode schizophrenia, hypothalamic-pituitary-adrenal axis activity (afternoon cortisol levels, post-dexamethasone cortisol levels) was evaluated before and at the end of acute treatment. Psychopathology was assessed using the positive and negative syndrome scale (PANSS). Cognitive functions (memory, attention, psychomotor, verbal fluency, and executive functions) were tested after symptom alleviation using a neurocognitive test battery. In the total sample (n=23), significant decreases in total PANSS score (including all subscales), afternoon cortisol levels, and post-dexamethasone cortisol levels occurred during the course of treatment. It was found that higher afternoon cortisol levels at the beginning of treatment were significantly related to impaired performance in memory functions. Afternoon cortisol levels were not significantly associated with other measured cognitive functions. No correlation was discovered between cognitive functions and post-dexamethasone cortisol levels. The determination of afternoon cortisol levels may serve to detect potential candidates for specific cognitive intervention immediately after the first psychotic breakthrough.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

STRESS

ISSN

1025-3890

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

383-389

UT code for WoS article

000382518400006

EID of the result in the Scopus database

2-s2.0-84975225208