Topiramate induced metabolic acidosis and kidney stones - a case study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801NF6" target="_blank" >RIV/61988987:17110/17:A1801NF6 - isvavai.cz</a>
Result on the web
<a href="http://www.biochemia-medica.com/2017/2/404" target="_blank" >http://www.biochemia-medica.com/2017/2/404</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.11613/BM.2017.042" target="_blank" >10.11613/BM.2017.042</a>
Alternative languages
Result language
angličtina
Original language name
Topiramate induced metabolic acidosis and kidney stones - a case study
Original language description
Introduction: The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones.Materials and methods: The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by potassium citrate, and after topiramate withdrawal are presented. Differential diagnosis of all possible causes of metabolic acidosis is discussed.Results: The results revealed negative base excess in extracellular fluid of - 9.2 mmol/L, low serum HCO3- concentration (18.6 mmol/L), trend to alkaline urine (pH 6.39) and low urine citrate concentration (0.3 mmol/24h). After topiramate withdrawal, all parameters of the internal environment normalized.Conclusions: This study has shown that long-term topiramate administration could induce metabolic acidosis and consequently urholithiasis. Thus, we could recommend testing blood acid base balance, urinary pH and citrates in patients taking topiramate and suffering from kidney stones.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHEMIA MEDICA
ISSN
1330-0962
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
2
Country of publishing house
HR - CROATIA
Number of pages
7
Pages from-to
404-410
UT code for WoS article
000404505700017
EID of the result in the Scopus database
2-s2.0-85020621263