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Carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801R57" target="_blank" >RIV/61988987:17110/17:A1801R57 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/17:00067060 RIV/00843989:_____/17:E0106430 RIV/61989592:15110/17:73581121

  • Result on the web

    <a href="http://dx.doi.org/10.1038/leu.2016.390" target="_blank" >http://dx.doi.org/10.1038/leu.2016.390</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/leu.2016.390" target="_blank" >10.1038/leu.2016.390</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR

  • Original language description

    The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n = 97 (25%); Vd, n = 113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n = 284 (75%); Vd, n = 291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45-0.92; P = 0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33-0.58; P &lt; 0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved &gt;= CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    LEUKEMIA

  • ISSN

    0887-6924

  • e-ISSN

    1476-5551

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    1368-1374

  • UT code for WoS article

    000402832700015

  • EID of the result in the Scopus database

    2-s2.0-85011631341