Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801RX3" target="_blank" >RIV/61988987:17110/17:A1801RX3 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00097992 RIV/65269705:_____/17:00067315 RIV/00098892:_____/17:N0000101 RIV/00843989:_____/17:E0106602

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijoa.2017.05.001" target="_blank" >http://dx.doi.org/10.1016/j.ijoa.2017.05.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijoa.2017.05.001" target="_blank" >10.1016/j.ijoa.2017.05.001</a>

Result language

angličtina

Original language name

Rocuronium versus suxamethonium for rapid sequence induction of general anaesthesia for caesarean section: influence on neonatal outcomes

Original language description

Background: In a previous study we compared rocuronium and suxamethonium for rapid-sequence induction of general anaesthesia for caesarean section and found no difference in maternal outcome. There was however, a significant difference in Apgar scores. As this was a secondary outcome, we extended the study to explore this finding on a larger sample.Methods: We included 488 parturients of whom 240 were women from the original study. Women were randomly assigned to receive either rocuronium 1 mg/kg (ROC n=245) or suxamethonium 1 mg/kg (SUX n=243) after propofol 2 mg/kg. Anaesthesia was maintained with up to 50% nitrous oxide and up to one minimum alveolar concentration of sevoflurane until the umbilical cord was clamped. We compared neonatal outcome using Apgar scores and umbilical cord blood gases.Results: Data were analysed for 525 newborns (ROC n=263 vs. SUX n=262). There was a statistically significant difference in the proportion of Apgar scores &lt; 7 at 1 min (ROC 17.5% vs. SUX 10.3%, P=0.023) but no difference at 5 min (ROC 8% vs. SUX 4.2%, P=0.1) or 10 min (ROC 3.0% vs. SUX 1.9%, P=0.58). There was no difference between groups in other measured outcomes.Conclusion: The use of rocuronium was associated with lower Apgar scores at 1 min compared with suxamethonium. The clinical significance of this is unclear and warrants further investigation. (C) 2017 Elsevier Ltd. All rights reserved.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30223 - Anaesthesiology

Project

<a href="/en/project/NT13906" target="_blank" >NT13906: Modern myorelaxation procedure and reversal of neuromuscular blockade with general anesthesia for caesarean section.</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA

ISSN

0959-289X

e-ISSN

1532-3374

Volume of the periodical

32

Issue of the periodical within the volume

11/2017

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

4-10

UT code for WoS article

000414110800002

EID of the result in the Scopus database

2-s2.0-85020469190