Anorectal dysfunction after laparoscopic low anterior rectal resection for rectal cancer with and without radiotherapy (manometry study)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901SW8" target="_blank" >RIV/61988987:17110/18:A1901SW8 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/18:E0107006
Result on the web
<a href="https://apps.webofknowledge.com/Search.do?product=WOS&SID=E5bsCQ5YbtRndnhjcDF&search_mode=GeneralSearch&prID=250a8788-cbe4-4812-b062-cbb92e1a5565" target="_blank" >https://apps.webofknowledge.com/Search.do?product=WOS&SID=E5bsCQ5YbtRndnhjcDF&search_mode=GeneralSearch&prID=250a8788-cbe4-4812-b062-cbb92e1a5565</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jso.24885" target="_blank" >10.1002/jso.24885</a>
Alternative languages
Result language
angličtina
Original language name
Anorectal dysfunction after laparoscopic low anterior rectal resection for rectal cancer with and without radiotherapy (manometry study)
Original language description
BACKGROUND AND OBJECTIVES:The aim was to evaluate the impact of radiotherapy (RT) on anorectal function of patients with low rectal cancer undergoing low anterior resection (LAR).METHODS:Prospective clinical cohort study conducted to assess the functional outcome by means of high-resolution anorectal manometry and LARS score.RESULTS:In total, 65 patients were enrolled in the study (27 patients underwent LAR without RT, 38 patients underwent RT and LAR). There were no statistically significant differences between study subgroups regarding demographic and clinical data; postoperative morbidity was significantly higher in irradiated patients. One year after the surgery, mean LARS score was significantly higher in patients who underwent RT and surgery. Major LARS was detected in 37.0% of irradiated patients and in 14.8% of patients after surgery alone. Anorectal manometry revealed significantly lower resting pressures in patients after RT and LAR; the squeeze pressures were similar. Rectal compliance and all volumes describing rectal sensitivity (first sensation, urge to defecate, and discomfort volume) were significantly lower in irradiated patients.CONCLUSIONS:RT significantly deteriorates the functional outcome of patients after LAR. Manometry revealed internal sphincter dysfunction, reduced capacity, and compliance of neorectum, which seem to have a significant correlation with LARS presence/seriousness.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
J SURG ONCOL
ISSN
0022-4790
e-ISSN
1096-9098
Volume of the periodical
117
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000428850300021
EID of the result in the Scopus database
2-s2.0-85044668156