Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901W35" target="_blank" >RIV/61988987:17110/18:A1901W35 - isvavai.cz</a>

Alternative codes found

RIV/71009396:_____/18:N0000020 RIV/61388971:_____/19:00505492 RIV/00216208:11310/19:10403108 RIV/71009396:_____/19:N0000001 RIV/27661989:_____/19:N0000015

Result on the web

<a href="http://dx.doi.org/10.1007/s12223-018-0661-9" target="_blank" >http://dx.doi.org/10.1007/s12223-018-0661-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12223-018-0661-9" target="_blank" >10.1007/s12223-018-0661-9</a>

Result language

angličtina

Original language name

Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature

Original language description

Cerebral abscesses caused by dark-pigmented Fonsecaea fungi are rare, especially in otherwise healthy individuals. In this casereport, we present a 61-year-old man from Moldova, living in the Czech Republic, who had worked as a locksmith on oilplatforms in Turkmenistan, Kazakhstan, Sudan, and Iraq since 1999, and was admitted to a neurology ward for a sudden motiondisorder of the right leg, dysarthria, and hypomimia. Imaging revealed presence of expansive focus around the left lateralventricle of the brain and a pronounced peripheral edema. The intracranial infectious focus was excised under intraoperativeSonoWand guidance. Tissue samples were histologically positive for dark-pigmented hyphae, suggesting dematiaceous fungi.Therefore, liposomal amphotericin B therapy was initiated immediately. Fonsecaea monophora was provisionally identifiedusing ITS rDNA region sequencing directly from brain tissue. The identification was subsequently confirmed by cultivation andDNA sequencing from culture. The strain exhibited in vitro sensitive to voriconazole (MIC = 0.016 ?g/mL) and resistance toamphotericin B (MIC = 4 ?g/mL); therefore, the amphotericin B was replaced with voriconazole. Postoperatively, a significantclinical improvement was observed and no additional surgery was required. Based on the literature review, this is the thirddocumented case of cerebral infection due to this pathogen in patients without underlying conditions and the first such case inEurope.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FOLIA MICROBIOLOGICA

ISSN

0015-5632

e-ISSN

1874-9356

Volume of the periodical

—

Issue of the periodical within the volume

9/2018

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85055705159