Free light chains in the cerebrospinal fluid. Do we still need oligoclonal IgG?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020PP" target="_blank" >RIV/61988987:17110/18:A20020PP - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/18:E0107126

Result on the web

<a href="https://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-7/cclm-2018-0096/cclm-2018-0096.pdf" target="_blank" >https://www.degruyter.com/downloadpdf/j/cclm.2018.56.issue-7/cclm-2018-0096/cclm-2018-0096.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/cclm-2018-0096" target="_blank" >10.1515/cclm-2018-0096</a>

Result language

angličtina

Original language name

Free light chains in the cerebrospinal fluid. Do we still need oligoclonal IgG?

Original language description

The diagnosis of multiple sclerosis (MS) is based on the demonstration of dissemination in space (DIS), i.e. involvement of different areas of the central nervous system (CNS), and dissemination in time (DIT), i.e. the occurrence of at least two relapses or, in the case of primary progressive MS, disability progression for at least 1 year. Magnetic resonance imaging (MRI) is the most important paraclinical test in patients with suspected MS that can demonstrate both DIS and DIT (i.e. simultaneous appearance of new and old lesions or appearance of new lesions over time). However, MRI findings lack pathological specificity, and an increasing proportion of MS patients is diagnosed after the first clinical episode suggestive of a demyelinating disease where the criterion of DIT might not be met. Demonstration of an inflammatory nature of the disease by means of CSF analysis, namely the presence of intrathecal humoral immune response, has been used for decades to support MS diagnosis, despite the fact that the importance of CSF analysis was de-emphasised in successive revisions of the McDonald MS diagnostic criteria [1]. The latest revision of these criteria, published ahead of print on December 21, 2017, revived the role of CSF analysis by stating that the presence of 2 or more oligoclonal bands (OCB) in the CSF absent from serum can substitute for the DIT criterion and thus enable determining the diagnosis of MS in patients with the first episode suggestive of a demyelinating disease (the so-called clinically isolated syndrome, CIS) if the DIS criteria are met [2].

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ISSN

1434-6621

e-ISSN

1437-4331

Volume of the periodical

56

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

1011-1014

UT code for WoS article

000433906000009

EID of the result in the Scopus database

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