Per-oral endoscopic myotomy (POEM): mid-term efficacy and safety

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA20020RI" target="_blank" >RIV/61988987:17110/18:A20020RI - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/18:00000435 RIV/00216224:14110/18:00102802 RIV/00216208:11110/18:10375376 RIV/00216208:11130/18:10375376 and 3 more

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007/s00464-017-5807-3.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00464-017-5807-3.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00464-017-5807-3" target="_blank" >10.1007/s00464-017-5807-3</a>

Result language

angličtina

Original language name

Per-oral endoscopic myotomy (POEM): mid-term efficacy and safety

Original language description

Abstract Background and aims Per-oral endoscopic myotomy (POEM) is becoming a standard treatment for achalasia. Long-term efficacy and the rate of post-POEM reflux should be further investigated. The main aim of this study was to analyze safety and mid-term (12 and 24 months) clinical outcomes of POEM. Methods Data on single tertiary center procedures were collected prospectively. The primary outcome was treatment success defined as an Eckardt score &lt;3 at 12 and 24 months. A total of 155 consecutive patients with achalasia underwent POEM; 133 patients were included into the analysis (22 patients will be analyzed separately as part of a multicenter randomized clinical trial). Results POEM was successfully completed in 132 (99.2%) patients, and the mean length of the procedure was 69.8 min (range 31-136). One patient underwent a drainage for pleural effusion; no other serious adverse events occurred. Treatment success at 3, 12, and 24 months was observed in 95.5% (CI 89.6-98.1), 93.4% (86.5-96.8), and 84.0% (71.4-91.4) of patients, respectively. A total of 11 patients (8.3%) reported initial treatment failure (n = 5) or later recurrence (n = 6). The majority of relapses occurred in patients with achalasia type I (16.7 vs. 1.1% achalasia type II vs. 0% achalasia type III; p &lt; 0.05). At 12 months, post-POEM reflux symptoms were present in 29.7% of patients. At 3 months, mild reflux esophagitis was diagnosed in 37.6% of patients, and pathological gastroesophageal reflux was detected in 41.5% of patients. A total of 37.8% of patients had been treated with a proton pump inhibitor. Conclusion POEM resulted in greater than 90% treatment success at 12 months which tends to decrease to 84% after 2 years. More than one-third of the patients had mild reflux symptoms and/or mild esophagitis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

ISSN

0930-2794

e-ISSN

1432-2218

Volume of the periodical

32

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1293-1302

UT code for WoS article

000424654800027

EID of the result in the Scopus database

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