What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA2001XY4" target="_blank" >RIV/61988987:17110/19:A2001XY4 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/19:E0107718
Result on the web
<a href="https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0044-101838" target="_blank" >https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0044-101838</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0044-101838" target="_blank" >10.1055/s-0044-101838</a>
Alternative languages
Result language
angličtina
Original language name
What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?
Original language description
Introduction The evaluation of plasma levels of antidepressants may improve the treatment outcome. The aim was to verify adherence and adequacy of administered doses of antidepressants among patients hospitalized for inadequate outpatient therapeutic response. Methods Selective serotonin reuptake inhibitors or venlafaxine plasma levels were assessed on the first day of hospitalization and after 3 days of controlled administration. The patients were considered adherent if the plasma level on admission was within the interval of the minimum and maximum plasma level on the fourth day, expanded by 30%. The adequacy of antidepressant doses used during the outpatient treatment was assessed by comparing the plasma level on the fourth day with the therapeutic reference range. Results Out of 83 patients, 52 (62.7%) were adherent. The plasma levels of antidepressants on the fourth day were found to be within the therapeutic reference range in 35 (43.2%) patients. The same number manifested levels below the therapeutic reference range. In 11 (13.6%) patients, the levels were higher than recommended. No significant difference in rate of adherence was found among individual antidepressants. Conclusion The results show that antidepressant nonresponders are frequently under-dosed or nonadherent.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacopsychiatry
ISSN
0176-3679
e-ISSN
1439-0795
Volume of the periodical
52
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
78-83
UT code for WoS article
000460173800004
EID of the result in the Scopus database
2-s2.0-85042231947