How Can Fatty Liver Lead to Liver Cancer and How Can We Simply Assess It?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA20022U3" target="_blank" >RIV/61988987:17110/19:A20022U3 - isvavai.cz</a>

Result on the web

<a href="https://actascientific.com/ASGIS/pdf/ASGIS-02-0100.pdf" target="_blank" >https://actascientific.com/ASGIS/pdf/ASGIS-02-0100.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.31080/ASGIS.2019.02.0100" target="_blank" >10.31080/ASGIS.2019.02.0100</a>

Result language

angličtina

Original language name

How Can Fatty Liver Lead to Liver Cancer and How Can We Simply Assess It?

Original language description

Background: In 2016, more than 1.9 billion adult populations were overweight, 650 million of them were obese, which represents around 13% of the world's adult population. Liver steatosis has become the most common chronic liver disease in developed countries. In most cases, non-alcoholic fatty liver disease (NAFLD) is a benign and reversible liver disorder. Under certain circumstances, the disease may result through the image of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis to liver cirrhosis with all known negative consequences, until formation of hepatocellular carcinoma (HCC). Methods: We searched from the Pubmed, Google Scholar and Research gate database and looked for keywords NAFLD, steatohepatitis, steatohepatitic variant of HCC. Results: The pathogenesis of NAFLD and metabolic syndrome seems to have common pathophysiological mechanisms. Although liver biopsy remains the gold standard for NAFLD diagnosis, it seems that new diagnostic procedures and scoring systems are emerging that could non-invasively distinguish simple steatosis from NASH. Conclusion: A higher number of metabolic syndrome risk factors have been registered in patients with steatohepatitic HCC variant. HCC patients with clinical symptoms have a very poor prognosis (median 5-year overall survival is between 0-10%); on the other hand, patients with asymptomatic HCC detected by screening show a higher survival rate, with a total 5-year survival of more than 50 % due to radical treatment. Simple and unassuming diagnostic methods can be used in a wide range of patients, thus systematically preventing the development of diseases and related disorders. Early diagnosis and risk stratification are essential for effective treatment management.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30212 - Surgery

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Scientific Gastrointestinal Disorders

ISSN

2582-1091

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

10

Country of publishing house

IN - INDIA

Number of pages

7

Pages from-to

37-43

UT code for WoS article

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EID of the result in the Scopus database

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