Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA200231U" target="_blank" >RIV/61988987:17110/19:A200231U - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/19:E0107796
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S1525505019301210?token=0DD9E9B0C859B3FC771D0F37A2864B6A0DD74EB2E96B0842B3BB4B3CA4A82C232E88AD133C454BE9637EF83A1790651E" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1525505019301210?token=0DD9E9B0C859B3FC771D0F37A2864B6A0DD74EB2E96B0842B3BB4B3CA4A82C232E88AD133C454BE9637EF83A1790651E</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yebeh.2019.04.002" target="_blank" >10.1016/j.yebeh.2019.04.002</a>
Alternative languages
Result language
angličtina
Original language name
Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy
Original language description
Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy. However, only a small number of studies have measured suckling infant serum levels of the drug. We studied the transport of VPA from breastfeeding mothers to the mature milk and breastfed infants and the influence of comedication with enzyme-inducing AEDs. The data of 30 nursing women treated by VPA were analyzed retro-spectively. Mature milk, maternal, and infant serum levels were collected between the 6th and 32nd postnatal day and measured by gas chromatography during the years 1996-2017. Valproic acid levels varied from 5.4 to 69.0 mg/L (mean: 39.0 +/- 16.1 mg/L) in the maternal serum, from <1.0 to 16.7 mg/L (mean: 1.6 +/- 3.9 mg/L) in the milk, and from <1.0 to 17.5 mg/L (mean: 4.2 = 4.3 mg/L) in the infant serum. The milk/maternal serum level ratio ranged from <0.03 to 0.25 (mean: 0.03 +/- 0.06) and the infant/maternal serum level ratio from <0.03 to 0.61 (mean: 0.11 +/- 0.13). Sixty-seven percent of milk and 33% of infant VPA concentrations were below the limit of quantification. No correlations were observed between maternal serum and milk levels or between maternal and infant serum levels. In conclusion, none of the milk or infant serum VPA levels reached the lower limit of the reference range used for the general population with epilepsy, so the degree of VPA exposure in breastfed infants is less than during gestation. Nevertheless, if signs of potential adverse reactions manifest, infant serum concentrations should be measured. Keywords: Valproic add Breastfeeding Milk Infant Therapeutic drug monitoring (C) 2019 Elsevier Inc. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10614 - Behavioral sciences biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EPILEPSY & BEHAVIOR
ISSN
1525-5050
e-ISSN
1525-5069
Volume of the periodical
95
Issue of the periodical within the volume
červen
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
112-116
UT code for WoS article
000469418500018
EID of the result in the Scopus database
2-s2.0-85064667607