Effect of human adipose-derived regenerative cells on temporomandibular joint healing in immunodeficient rabbits
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA20023FM" target="_blank" >RIV/61988987:17110/19:A20023FM - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/19:43877295 RIV/00843989:_____/19:E0107772
Result on the web
<a href="https://actavet.vfu.cz/media/pdf/actavet_2019088010049.pdf" target="_blank" >https://actavet.vfu.cz/media/pdf/actavet_2019088010049.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb201988010049" target="_blank" >10.2754/avb201988010049</a>
Alternative languages
Result language
angličtina
Original language name
Effect of human adipose-derived regenerative cells on temporomandibular joint healing in immunodeficient rabbits
Original language description
Increasing research attention has focused on the use of stem cells (SCs) in regenerative and reparative medicine. Adipose-derived regenerative cells (ADRCs) are a relatively cheap and ethical source of SCs. Temporomandibular disorders (TMDs) have been reported with rising incidence over recent decades. The main aims of this study were to evaluate the effects of ADRCs application on the healing of both soft and hard temporomandibular joint (TMJ) tissues, and to assess the possible utilization of ADRCs in TMD treatment. We investigated the effects of human ADRCs on the healing of TMJ defects in immunodeficient rabbits. With no prior cultivation, ADRCs were applied to a surgically created defect in the cartilage of a rabbit TMJ. The healing process and inflammatory response were examined. Our results indicated that ADRCs supported repair processes in soft tissues. However, ADRC treatment induced a significant immune response in both soft and hard tissues, with hard tissues showing a higher level of bone remodelling. Non-differentiated ADRCs can be a promising tool for regenerative medicine of TMJ; however, deeper understanding of their effect on the cellular level is needed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40300 - Veterinary science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACTA VETERINARIA BRNO
ISSN
0001-7213
e-ISSN
1801-7576
Volume of the periodical
88
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
49-56
UT code for WoS article
000468126600007
EID of the result in the Scopus database
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