Bortezomib Retreatment Is Effective in Relapsed Multiple Myeloma Patients - Real-Life Clinical Practice Data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA21025LQ" target="_blank" >RIV/61988987:17110/20:A21025LQ - isvavai.cz</a>

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/31829027/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31829027/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2019_190430N383" target="_blank" >10.4149/neo_2019_190430N383</a>

Result language

angličtina

Original language name

Bortezomib Retreatment Is Effective in Relapsed Multiple Myeloma Patients - Real-Life Clinical Practice Data

Original language description

Nowadays, bortezomib, a proteasome inhibitor, is widely used in treatment of newly diagnosed or relapsed multiple myeloma. The aim of this study was to analyze efficiency of bortezomib retreatment in patients with relapsed or refractory multiple myeloma. From 2004 to 2016, 283 patients were retrospectively evaluated at all hematological centers in the Czech Republic. Bortezomib was administered at the standard dosing and in combined therapy with corticosteroids, chemotherapy or thalidomide. Before bortezomib retreatment, 61% of patients received previous lenalidomide treatment, 40.6% autologous transplantation, and median number of prior lines of therapy was three. In total, 21% of patients were refractory to the first bortezomib treatment. In bortezomib retreatment, overall response rate was 34.5%, median progression-free survival was 7.8 months (95% CI: 6.7–8.9), median duration of response was 10.5 months (95% CI: 8.0–13.0) and median overall survival was 20.3 months (95% CI: 17.9–22.7). Grade 3-4 adverse events included thrombocytopenia, neutropenia, anemia and infection. Neuropathy grade 2 or higher occurred in 19.4% of patients. We conclude that bortezomib retreatment is an effective and safe therapeutic alternative for relapsed or refractory multiple myeloma patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

1338-4317

e-ISSN

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Volume of the periodical

67

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

178-184

UT code for WoS article

000542659200021

EID of the result in the Scopus database

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