Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA21027K6" target="_blank" >RIV/61988987:17110/20:A21027K6 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/20:00531425 RIV/00843989:_____/20:E0108531 RIV/00216208:11110/20:10415116 RIV/00216208:11310/20:10415116
Result on the web
<a href="https://www.embopress.org/doi/pdf/10.15252/embj.2019104202" target="_blank" >https://www.embopress.org/doi/pdf/10.15252/embj.2019104202</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15252/embj.2019104202" target="_blank" >10.15252/embj.2019104202</a>
Alternative languages
Result language
angličtina
Original language name
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop
Original language description
IL-17 mediates immune protection from fungi and bacteria, as well as it promotes autoimmune pathologies. However, the regulation of the signal transduction from theIL-17 receptor (IL-17R) remained elusive. We developed a novel mass spectrometry-based approach to identify components of theIL-17R complex followed by analysis of their roles using reverse genetics. Besides the identification of linear ubiquitin chain assembly complex (LUBAC) as an important signal transducing component ofIL-17R, we established thatIL-17 signaling is regulated by a robust negative feedback loop mediated byTBK1 andIKK epsilon. These kinases terminateIL-17 signaling by phosphorylating the adaptorACT1 leading to the release of the essential ubiquitin ligaseTRAF6 from the complex.NEMOrecruits both kinases to theIL-17R complex, documenting thatNEMOhas an unprecedented negative function inIL-17 signaling, distinct from its role inNF-kappa B activation. Our study provides a comprehensive view of the molecular events of theIL-17 signal transduction and its regulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Journal
ISSN
0261-4189
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
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UT code for WoS article
000566991800004
EID of the result in the Scopus database
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