Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA2102881" target="_blank" >RIV/61988987:17110/20:A2102881 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00118096 RIV/00216208:11150/20:10418791 RIV/00179906:_____/20:10418791 RIV/00843989:_____/20:E0108657

Result on the web

<a href="https://www.nature.com/articles/s41598-020-78434-8" target="_blank" >https://www.nature.com/articles/s41598-020-78434-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-020-78434-8" target="_blank" >10.1038/s41598-020-78434-8</a>

Result language

angličtina

Original language name

Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis

Original language description

We aimed was to assess the factors influencing therapy choice and clinical outcome after 3-4 months in patients with cerebral venous sinus thrombosis (CVST). In a retrospective, bi-centric study, the set consisted of 82 consecutive CVST patients (61 females; mean age 33.5 +/- 15.7 years). Following data were collected: baseline characteristics, presence of gender-specific risk factors (GSRF), location and extent of venous sinus impairment, clinical presentation, type of treatment, recanalization, presence of parenchymal lesions, and clinical outcome after 3-4 months (assessed using the modified Rankin Scale [mRS], with excellent outcome defined as mRS 0-1). Multivariate logistic regression analysis was used for statistical evaluation. After 3-4 months, complete recovery was achieved in 41 (50%) and excellent clinical outcome in 67 (81.7%) patients. Female sex (OR 0.11; p=0.0189) and presence of focal neurologic deficit (OR 0.16; p=0.0165) were identified as significant independent negative predictors and, the presence of GSRF (OR 15.63; p=0.0011) as significant independent positive predictor of excellent clinical outcome. In conclusion, in our CVST patients, the presence of GSRF was associated with excellent clinical outcome, while the female sex itself was associated with poorer clinical outcome.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

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UT code for WoS article

000609190200007

EID of the result in the Scopus database

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