Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202DJP" target="_blank" >RIV/61988987:17110/21:A2202DJP - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/21:E0109187 RIV/65269705:_____/21:00074672 RIV/00216224:14110/21:00120117 RIV/00209805:_____/21:00078870

Result on the web

<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000691097800005" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000691097800005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4251/wjgo.v13.i8.835" target="_blank" >10.4251/wjgo.v13.i8.835</a>

Result language

angličtina

Original language name

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

Original language description

Helicobacter pylori (H. pylori) is an infectious agent influencing as much as 50% of the world's population. It is the causative agent for several diseases, most especially gastric and duodenal peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma of the stomach. A number of other, extragastric manifestations also are associated with H. pylori infection. These include neurological disorders, such as Alzheimer's disease, demyelinating multiple sclerosis and Parkinson's disease. There is also evidence for a relationship between H. pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma. Generally little is known about the relationship between H. pylori infection and diseases of the pancreas. Most evidence about H. pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis. There is data (albeit not fully consistent) indicating modestly increased pancreatic cancer risk in H. pylori-positive patients. The pathogenetic mechanism of this increase is not yet fully elucidated, but several theories have been proposed. Reduction of antral D-cells in H. pylori-positive patients causes a suppression of somatostatin secretion that, in turn, stimulates increased secretin secretion. That stimulates pancreatic growth and thus increases the risk of carcinogenesis. Alternatively, H. pylori, as a part of microbiome dysbiosis and the so-called oncobiome, is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation. The role of H. pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins (mostly enzymes) of H. pylori and pancreatic tissue.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NU20-03-00126" target="_blank" >NU20-03-00126: Host microbiome in relation to Barrett´s esophagus and esophageal adenocarcinoma development</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

835-844

UT code for WoS article

000691097800005

EID of the result in the Scopus database

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