A Review of Molecular and Genetic Diagnostics of Myeloid Malignancies with Emphasis on Diagnostics in Bosnia and Herzegovina

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202EMA" target="_blank" >RIV/61988987:17110/21:A2202EMA - isvavai.cz</a>

Result on the web

<a href="http://www.ama.ba/index.php/ama/article/view/453" target="_blank" >http://www.ama.ba/index.php/ama/article/view/453</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5644/ama2006-124.334" target="_blank" >10.5644/ama2006-124.334</a>

Result language

angličtina

Original language name

A Review of Molecular and Genetic Diagnostics of Myeloid Malignancies with Emphasis on Diagnostics in Bosnia and Herzegovina

Original language description

Here we describe the major genetic and genomic aberrations found in myeloid malignancies and how those markers are used in patients' diagnosis, prognosis, and targeted treatment. In Bosnia and Herzegovina, cytogenetic and molecular diagnostics for myeloid malignancies have been established and continually improved since 2005. We report the current state of available diagnostic tools for myeloid malignancies in Bosnia and Herzegovina. Myeloid malignancies are a heterogeneous group of clonal blood diseases characterized by defects in hematopoietic stem cells and myeloid progenitors that lead to abnormal proliferation, differentiation, localization, and self-renewal. Most common myeloid malignancies include myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML). Molecular diagnostics of myeloid malignancies have significantly expanded in the last decade with new genetic and genomic markers for diagnosis, prognosis, and treatment. CONCLUSION: In the last decade, several new genomic markers important for patient diagnosis, prognosis, and therapy have been discovered that need to be implemented in routine molecular diagnostics not only in developed nations but also in developing nations such as Bosnia and Herzegovina. Copyright © 2021 by Academy of Sciences and Arts of Bosnia and Herzegovina.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta medica academica

ISSN

1840-2879

e-ISSN

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Volume of the periodical

50

Issue of the periodical within the volume

1

Country of publishing house

BA - BOSNIA AND HERZEGOVINA

Number of pages

22

Pages from-to

175-196

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85107424236